New Chiral Brønsted Acid for Asymmetric Reduction of Indoles
نویسندگان
چکیده
منابع مشابه
Chiral transition-metal complexes as Brønsted-acid catalysts for the asymmetric Friedel-Crafts hydroxyalkylation of indoles.
The Friedel-Crafts reaction between 3,3,3-trifluoropyruvates and indoles is efficiently catalysed by the iridium complex [(η(5)-C5Me5)Ir{(R)-Prophos}(H2O)][SbF6]2 (1) with up to 84% ee. Experimental data and theoretical calculations support a mechanism involving the Brønsted-acid activation of the pyruvate carbonyl by the protons of the coordinated water molecule in 1. Water is not dissociated ...
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While a variety of protocols, including traditional enzymatic or non-enzymatic kinetic resolutions, and organicmoleculeor metal-mediated asymmetric transformations have been described, the direct asymmetric reduction of prochiral indole precursors would be one of the most straightforward ways to make chiral indolines. Thus, a few transition metal/chiral phosphine complexes, including Rh, Ru, an...
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The indole skeleton is the most universal heterocycle structure in nature and is well established as a privileged scaffold; it is commonly encountered in many biologically active natural products and pharmaceutical compounds. Owing to the great structural diversity of biologically active indoles, indole units are of great importance in medicinal chemistry and are widely used in the pharmaceutic...
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The catalytic enantioselective allylation of aldehydes is a long-standing problem of considerable interest to the chemical community. We disclose a new high-yielding and highly enantioselective chiral Brønsted acid-catalyzed allylboration of aldehydes. The reaction is shown to be highly general, with a broad substrate scope that covers aryl, heteroaryl, alpha,beta-unsaturated, and aliphatic ald...
متن کاملSynthesis of Fused Polycyclic Indoles by Brønsted Acid-Catalyzed Intramolecular Alkylation of Indoles with Alcohols.
An efficient methodology for the synthesis of a series of new fused polyclyclic indoles has been developed by Brønsted acid-catalyzed intramolecular Friedel-Crafts reactions of properly designed indolyl alcohols.
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2020
ISSN: 0253-2786
DOI: 10.6023/cjoc202000039